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apalutamide will decrease the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medication which are CYP3A4 substrates may result in reduce publicity to those drugs.posaconazole will increase the level or influe